Vincenzo Grifo was born on 07/04/1993 inPforzheim, Germany. Grifo began his footballing career with CfR Pforzheim and Germania Brötzingen, before joining Karlsruher SC in 2011. In July 2012, he joined Hoffenheim on a free transfer. In the summer of 2013. He spent the next seasons on loan with Dynamo Dresden and FSV Frankfurt. His performances led SC Freiburg to purchase him. On 28 May 2017, Borussia Mönchengladbach announced the signing of Grifo. On 11 June 2018, Hoffenheim signed Grifo on a four-year deal.On 6 January 2019, he returned to Freiburg until the end of 2018–19 season.